| Target | Name | Strain | Tissue | PubMed | Comment/Method | |
| Ca++ | ||||||
| Ca++ | MIP-YC3.3-er mice | CD1 | Langerhans' islands | Hara 2004 | ||
| Ca++ | orexin/YC2.1 mice | BDF1 | neuron | Tsujino 2005 | ||
| Ca++ | Thy1/CerTN-L15 | C57BL/6 | neuron | Heim 2007 | ||
| Ca++ | S100β-YC-C (YC 3.60) | C57BL6/J | glia | Atkin 2009 | ||
| cAMP, ATP | ||||||
| cAMP | HCN2-camps | cardiomyocyte | Nikolaev 2006 | α-myosin heavy chain promoter | ||
| cAMP | cAMP-sensor mice | FVB | ubiquitous | Calebiro 2009 | CAG promoter | |
| ATP | Thy1-ATeam | C57BL/6J | pan-neuronal | Trevisiol 2017 | Thy1.2 promoter | |
| ATP | GO-ATeam2 | C57BL/6J | ubiquitous | Yamamoto 2019 | CAG promoter in Rosa26 locus | |
| Caspases | ||||||
| Caspase 3 | ROSA-lox-stop-lox-SCAT3.1 knock-in (KI) mice | BDF1 | Cre-inducible | Tomura 2009 | ||
| Caspase 3 | SCAT3-TG mice | C57BL/6 | ubiquitous | Yamaguchi 2011 | CAG promoter/2xHS4 insulator | |
| Protein kinases | ||||||
| MLCK | pSM8 35 KCS | CD1 | smooth muscle | Isotani 2004 | smooth muscle α-actin promoter | |
| ERK | Eisuke | C57BL/6 | ubiquitous | Kamioka 2012 | CAG promoter/Tol2 transposon | |
| Others | from Matsuda Lab | |||||
| Low molecular weight GTPases | ||||||
| Rac1 | Rac-FRET mouse | C57BL/6 | Cre-inducible | Johnsson 2014 | ROSA26 | |
| RhoA | Rho-FRET mouse | C57BL/6 | Cre-inducible | Nobis 2017 | ROSA26 | |
| Others | from Matsuda Lab | |||||