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京都大学大学院生命科学研究科博士課程(5年制)   戻る
日野直也(平成29年(博士編入)―31年度、修了):
An amphipathic helix of vinexin α is necessary for a substrate stiffness-dependent conformational change in vinculin. Hino N, Ichikawa T, Kimura Y, Matsuda M, Ueda K, Kioka N. J Cell Sci.132(2). pii: jcs217349. doi: 10.1242/jcs.217349. (2019)

今西彩子(平成27年―31年度、修了):
A novel morphological marker for the analysis of molecular activities at the single-cell level. Imanishi A, Murata T, Sato M, Hotta K, Imayoshi I, Matsuda M, Terai K. Cell Struct Funct. 44(2):153-169. (2018) doi: 10.1247/csf.18035.

真流玄武(平成26年―30年度、修了):
Multiplexed Fluorescence Imaging of ERK and Akt Activities and Cell-cycle Progression. Maryu G, Matsuda M, Aoki K. Cell Struct Funct. 41(2):81-92, (2016).

小長谷有美(平成26年―30年度、修了):
A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs. Konagaya Y, Terai K, Hirao Y, Takakura K, Imajo M, Kamioka Y, Sasaoka N, Kakizuka A, Sumiyama K, Asano T, Matsuda M. Cell Rep. 21(9):2628-2638, (2017).

三浦晴子(平成28年(博士編入)―29年度、修了):
Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death. Miura, H., Kondo, Y., Matsuda, M. Aoki, K. Cell Rep. 24, 2658-2668, (2018).

李春杰(平成26年(博士編入)―28年度、修了):
A FRET biosensor for ROCK based on a consensus substrate sequence identified by KISS technology. Li C, Imanishi A, Komatsu N, Terai K, Amano M, Kaibuchi K, Matsuda M. Cell Struct Funct. 42:1-13, (2017).

櫻井敦朗(平成22年―26年度、修了):
Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis. Sakurai A, Matsuda M, Kiyokawa E. J Biol Chem 2012 287(38):31703-11, (2012).

定家 和佳子(平成22年―26年度、修了):
Sadaie W, Harada Y, Matsuda M, Aoki K. Quantitative in vivo fluorescence cross-correlation analyses highlight the importance of competitive effects in the regulation of protein-protein interactions. Mol Cell Biol. 34(17):3272-90, (2014).

小松直貴(平成21年―25年度、修了):
Komatsu N, Aoki K, Yamada M, Yukinaga H, Fujita Y, Kamioka Y, and Matsuda M. Development of an optimized backbone of FRET biosensors for kinases and GTPases. Mol Biol Cell22:4647-5633, (2011).

熊谷悠香(平成21年―25年度、修了):
Kumagai Y, Naoki H, Kamioka Y, Kiyokawa E and Matsuda, M. Heterogeneity in ERK activity as visualized by in vivo FRET imaging of mammary tumor cells developed in MMTV-Neu mice. Oncogene 34:1051-1057, (2014); Kumagai Y, Kamioka Y, Yagi S, Matsuda M, and Kiyokawa E. A genetically encoded Forster resonance energy transfer biosensor for two-photon excitation microscopy. Anal Biochem 413(2):192-9, (2011).

後藤明弘(平成20年―24年度、修了):
Goto, A., Sumiyama, K., Kamioka, Y., Nakasyo, E., Ito, K., Iwasaki, M., Enomoto, H. & Matsuda, M. GDNF and endothelin 3 regulate migration of enteric neural crest-derived cells via protein kinase A and Rac1.J. Neurosci.33, 4901-4912, (2013); Goto, A., Hoshino, M., Matsuda, M. & Nakamura, T. Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells. Mol Biol Cell22, 1780-1790, (2011).

八木俊輔(平成20年―24年度、修了):
Yagi, S., Matsuda, M. & Kiyokawa, E. Chimaerin suppresses rac1 activation at the apical membrane to maintain the cyst structure.PLoS One 7, e52258, (2012); Yagi, S., Matsuda, M. & Kiyokawa, E. Suppression of Rac1 activity at the apical membrane of MDCK cells is essential for cyst structure maintenance. EMBO Rep. 13, 237-243, (2012).

西岡 照子(平成18年―22年、修了):
Nishioka T, Frohman A. M, Matsuda M, and Kiyokawa E. Heterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a forster resonance energy transfer (fret) biosensor J Biol Chem.12;285(46):35979-87.2010; Nishioka T, Aoki K, Hikake K, Yoshizaki H, Kiyokawa E, and Matsuda M. Rapid Turnover Rate of Phosphoinositides at the Front of Migrating MDCK Cells. Mol Biol Cell19:4213-4223.2008


京都大学大学院医学研究科医科学博士課程(5年制)   戻る
宇田洋一(平成27年(編入)―30年度、修了):
Efficient synthesis of phycocyanobilin in mammalian cells for optogenetic control of cell signaling. Uda Y, Goto Y, Oda S, Kohchi T, Matsuda M, Aoki K. Proc Natl Acad Sci U S A. 114(45):11962-11967, (2017).


京都大学大学院医学研究科医学博士課程(4年制)   戻る
金城智章(平成28年―31年度、修了):
FRET-assisted photoactivation of flavoproteins for in vivo two-photon optogenetics. Kinjo T, Terai K, Horita S, Nomura N, Sumiyama K, Togashi K, Iwata S, Matsuda, M. Nat Methods 10:98-113, (2019).

小西義延(平成27年―30年度、修了):
Live-Cell FRET Imaging Reveals a Role of Extracellular Signal-Regulated Kinase Activity Dynamics in Thymocyte Motility. Konishi Y, Terai K, Furuta Y, Kiyonari H, Abe T, Ueda Y, Kinashi T, Hamazaki Y, Takaori-Kondo A, Matsuda M. iScience. 10:98-113, (2018).

牟田優(平成26年―29年度、修了):
Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine. Muta Y, Fujita Y, Sumiyama K, Sakurai A, Taketo MM, Chiba T, Seno H, Aoki K, Matsuda M, Imajo M. Nat Commun. 9(1):2174, (2018).

佐野剛視(平成25年―28年度、修了):
Sano, T., Kobayashi, T., Ogawa, O., Matsuda, M. Gliding Basal Cell Migration of the Urothelium during Wound Healing. Am. J. Pathol. 188, 2564-2573, (2018); Sano T, Kobayashi T, Negoro H, Sengiku A, Hiratsuka T, Kamioka Y, Liou LS, Ogawa O, Matsuda M.Intravital imaging of mouse urothelium reveals activation of extracellular signal-regulated kinase by stretch-induced intravesical release of ATP. Physiol Rep. 2016 Sep 2;11(9):e0162300. doi: 10.1371/journal.pone.0162300.

河鰭憲幸(平成25年―28年度、修了):
Kawabata N, Matsuda M.
Cell Density-Dependent Increase in Tyrosine-Monophosphorylated ERK2 in MDCK Cells Expressing Active Ras or Raf.
PLoS One. 2016 Dec 9;11(12):e0167940. doi: 10.1371/journal.pone.0167940.

奥知慶久(平成24年―27年度、修了):
Okuchi Y, Imajo M, Mizuno R, Kamioka Y, Miyoshi H, Taketo MM, Nagayama S, Sakai Y, Matsuda M. Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis. PLoS One. 2016 Sep 2;11(9):e0162300. doi: 10.1371/journal.pone.0162300.

平塚徹(平成23年―26年度、修了):
Hiratsuka T, Fujita Y, Naoki H, Aoki K, Kamioka Y, Matsuda M. Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin. eLife 4:e05178. (2015).

藤田芳久(平成22年―26年度、修了):
Fujita Y, Komatsu N, Matsuda M, Aoki K. FRET-based quantitative analysis of feedforward and feedback loops in EGFR signaling and the sensitivity to molecular targeting drugs. FEBS J. 2014 doi: 10.1111/febs.12852.

水野礼(平成22年―25年度、修了):
Mizuno R, Kamioka Y, Kabashima K, Imajo M, Sumiyama K, Nakasho E, Ito T, Hamazaki Y, Okuchi Y, Sakai Y, Kiyokawa E, Matsuda M. In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines. J Exp Med. 2014 doi: 10.1084/jem.20132112

幸長弘子(平成21年―24年度、修了):
Yukinaga H, Shionyu C, Hirata E, Ui-Tei K, Nagashima T, Kondo S, Okada-Hatakeyama M, Naoki H, Matsuda M. Slow fluctuation of Rac1 activity is associated with biological and transcriptional heterogeneity of glioma cells. J Cell Sci. 2014 PMID: 24522191

国田勝行(平成20年―23年、修了):
Kunida K, Matsuda M, and Aoki K. FRET imaging and statistical signal processing reveal positive and negative feedback loops regulating the morphology of randomly migrating HT-1080 cells. J Cell Sci 125, 2381-2392, (2012).

平田英周(平成20年―23年、修了):
Hirata E, Yukinaga H, Kamioka Y, Arakawa Y, Miyamoto S, Okada T, Sahai E, and Matsuda M.. In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion. J Cell Sci. 125:858-868, (2012).

橘 充弘(平成17年―20年、修了):
Tachibana M, Kiyokawa E, Hara S, Iemura SI, Natsume T, Manabe T, and Matsuda M. Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation. Exp Cell Res. 10;315(5):863-876, 2009.


京都大学大学院医学研究科論文博士  戻る
山内文生(平成24年―28年):
Yamauchi F, Kamioka Y, Yano T, Matsuda M. In Vivo FRET Imaging of Tumor Endothelial Cells Highlights a Role of Low PKA Activity in Vascular Hyperpermeability. Cancer Res. 2016 Sep 15;76(18):5266-76. doi: 10.1158/0008-5472.CAN-15-3534

吉木さやか(平成17年―23年):
Yoshiki S, Matsunaga-Udagawa R, Aoki K, Kamioka Y, Kiyokawa E, and Matsuda M. Ras and calcium signaling pathwaysconverge at Raf1 via the Shoc2 scaffold protein. Mol Biol Cell. 21(6):1088-96, (2010).


大阪大学大学院医学研究科博士課程(4年制)  戻る
原 重雄(平成17年―20年、早期修了):
S. Hara, E. Kiyokawa, S. I. Iemura, T. Natsume, T. Wassmer, P. J. Cullen, H. Hiai, and M. Matsuda. The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport. Mol.Biol.Cell 19:3823-3835, 2008.

北野 正寛(平成17年―20年、早期修了):
M. Kitano, M. Nakaya, T. Nakamura, S. Nagata, and M. Matsuda. Imaging of Rab5 activity identifies essential regulators for phagosome maturation. Nature 453:241-245, 2008.

寺井 健太(平成14年―18年):
K. Terai and M. Matsuda. Ras binding opens c-Raf to expose the docking site for MEK. EMBO Rep. 6:251-255, 2005; K. Terai and M. Matsuda. The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf. EMBO J. 25:3556-3564, 2006.

高谷 昭行(平成14年―18年):
A. Takaya, Y. Ohba, K. Kurokawa, and M. Matsuda. RalA activation at nascent lamellipodia of EGF-stimulated Cos7 cells and migrating MDCK cells. Mol.Biol.Cell 15:2549-2557, 2004; A. Takaya, A. Kamio, M. Masuda, N. Mochizuki, H. Sawa, M. Sato, K. Nagashima, A. Mizutani, A. Matsuno, E. Kiyokawa, and M. Matsuda. R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes. Mol.Biol.Cell 18:1850-1860, 2007.

藤岡 亜紀(平成14年―18年):
A. Fujioka, K. Terai, R. E. Itoh, K. Aoki, T. Nakamura, S. Kuroda, E. Nishida, and M. Matsuda. Dynamics of the RAS/ERK map kinase cascade as monitored by fluorescence probes. J.Biol.Chem. 281:8917-8926, 2006.

大阪大学大学院医学研究科修士課程―博士課程(6年制)  戻る
青木 一洋(平成14年―19年、早期修了):
K. Aoki, T. Nakamura, and M. Matsuda. Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells. J.Biol.Chem. 279:713-719, 2004; K. Aoki, T. Nakamura, K. Fujikawa, and M. Matsuda. Local PIP3 accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol.Biol.Cell 16:2207-2217, 2005; K. Aoki, T. Nakamura, T. Inoue, T. Meyer, and M. Matsuda. An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of NGF-stimulated PC12 cells. J.Cell Biol. 177:817-827, 2007.

伊藤 玲奈(平成13年―19年):
R. E. Itoh, K. Kurokawa, Y. Ohba, H. Yoshizaki, N. Mochizuki, and M. Matsuda. Activation of Rac and Cdc42 video-imaged by FRET-based single-molecule probes in the membrane of living cells. Mol.Cell.Biol. 22:6582-6591, 2002; R. E. Itoh, K. Kurokawa, A. Fujioka, A. Sharma, B. J. Mayer, and M. Matsuda. A FRET-based probe for epidermal growth factor receptor bound non-covalently to a pair of synthetic amphipathic helixes. Exp.Cell Res. 307:142-152, 2005.



大阪大学大学院医学研究科論文博士  戻る
吉崎 尚良(平成13年―18年):
H. Yoshizaki, Y. Ohba, K. Kurokawa, R. E. Itoh, T. Nakamura, N. Mochizuki, K. Nagashima, and M. Matsuda. Activity of Rho-family GTPases during cell division as visualized with FRET-based probes. J.Cell Biol. 162:223-232, 2003; H. Yoshizaki, Y. Ohba, M. C. Parrini, N. G. Dulyaninova, A. R. Bresnick, N. Mochizuki, and M. Matsuda. Cell type-specific regulation of RhoA activity during cytokinesis. J.Biol.Chem. 279:44759-44762, 2004; H. Yoshizaki, N. Mochizuki, Y. Gotoh, and M. Matsuda. Akt-PDK1 Complex Mediates EGF-induced Membrane Protrusion through Ral Activation. Mol.Biol.Cell 18:119-128, 2007.

川瀬 一穂(平成16年―18年):
K. Kawase, T. Nakamura, A. Takaya, K. Aoki, K. Namikawa, H. Kiyama, S. Inagaki, H. Takemoto, A. R. Saltiel, and M. Matsuda. GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion. Dev.Cell 11:411-421, 2006.

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