Jan 24, 2021
All mice are generated by Kenta Sumiyama@QBiC except ROSA26-targed mice developed by Takaya Abe@CDB.
| Target | Alias | Transgene | Strain | ID | Tissue | Reference etc. | |
| Protein kinases | |||||||
| ERK | Eisuke | EKAREV-NES | B6-Tg(EKAREV)pT2A-3903NES | nbio_183 | Ubiquitous |
Kamioka 2012;
Mizuno 2014;
Okuchi 2016;
Sano 2016;
Yamauchi 2016;
Hiratsuka 2017;
Ihermann-Hella 2018;
Muta 2018;
Sano 2018;
Genotyping |
|
| ERK | Balb/c.Eisuke-NES | EKAREV-NES | Balb/c-Tg(EKAREV)pT2A-3903NES | nbio_284 | Ubiquitous | ||
| ERK | hyBRET-Eisuke | hyBRET-ERK-NES | B6 Albino-Tg(hyBRET-ERK-NES)pT2A-6011NES | nbio_325 | Ubiquitous | Komatsu 2018; Imanishi 2018 | |
| ERK | R26R-EKAREV-NES | EKAREV-NES | Gt(ROSA)26Sortm1(CAG-loxP-tdKeima-loxP-EKAREV-NES) | CDB0306K | Cre-inducible | Konishi 2018 | |
| ERK | ERK-NES-B6 Albino | EKAREV-NES | B6 Albino-Tg(EKAREV)pT2A-3903NES | nbio_332 | Ubiquitous | ||
| ERK | lox-Eisuke | EKAREV-NES | B6-Tg(EKAREV)pT2A-lox-tdKeima-3903NES | nbio_211 | Cre-inducible | Goto 2015; Yamaguchi 2015 | |
| ERK | FVB.lox-Eisuke-NES | EKAREV-NES | FVB.Tg(lox-EKAREV)pT2A-lox-tdKeima-3903NES | nbio_274 | Cre-inducible | ||
| ERK | lox-HyBRET-ERK-NES | hyBRET-EKAREV-NES | B6 Albino-Tg(loxP-mCherry-NES-loxP-hyBRET-EKAREV-NES) | Under preparation. | Cre-inducible | ||
| ERK | Eisuke-NLS | EKAREV-NLS | B6-Tg(EKAREV)pT2A-3905NLS | nbio_184 | Ubiquitous | Kamioka 2012 | |
| ERK | hyBRET-Eisuke-NLS | hyBRET-ERK-NLS | B6 Albino-Tg(hyBRET-ERK-NLS)pT2A-6011NLS | nbio_326 | Ubiquitous | Komatsu 2018; Kinjo 2019; Yoshida 2020; Ishii 2021 | |
| ERK | R26R-EKAREV-NLS | EKAREV-NLS | Gt(ROSA)26Sortm1(CAG-loxP-tdKeima-loxP-EKAREV-NLS) | CDB0307K | Cre-inducible | Konishi 2018; Konagaya 2020 | |
| ERK | FVB.Eisuke-NLS | EKAREV-NLS | FVB-Tg(EKAREV)pT2A-3905NLS(N6) | nbio_255 | Ubiquitous | Kamioka 2012; Hiratsuka 2015; Aoki 2017 | |
| ERK/ Calcium | lox-hyBRET-ERK-NLS-RGECO | lox-tdKeima-NES-stop-lox-6011nls-P2Av3-RGECO1 | B6 Albino-Tg(loxP-tdKeima-NES-stop-loxP-6011nls-P2Av3-RGECO1) | Under preparation. | Cre-inducible | ||
| ERK | lox-HyBRET-ERK-NLS | hyBRET-EKAREV-NLS | B6 Albino-Tg(loxP-mCherry-NES-loxP-hyBRET-EKAREV-NLS) | Under preparation. | Cre-inducible | ||
| ERK | ERK-NLS-B6 Albino | EKAREV-NLS | B6 Albino-Tg(EKAREV)pT2A-3905NLS | nbio_333 | Ubiquitous | ||
| JNK | Junko | JNKAR1EV | ICR×(ICR×B6C3F1)N2- Tg(pT2A-3907NLS) | nbio_189 | Ubiquitous | Goto 2013 | |
| ATM | Bruce | Eevee-ATM | B6C3F1-Tg(pT2A-lox-tdKeima-FHA1-TQCHK2subs) | nbio_189 | Cre-inducible | ||
| PKA | PKAchu | AKAREV | B6-Tg(AKAR3EV)pT2A-3901NES | nbio_185 | Ubiquitous |
Kamioka 2012;
Mizuno 2014;
Okuchi 2016;
Sano 2016;
Yamauchi 2016;
Hiratsuka 2017;
Sato 2020; Genotyping |
|
| PKA | Balb/c.PKAchu | AKAREV | Balb/c-Tg(AKAR3EV)pT2A-3901NES | nbio_283 | Ubiquitous | ||
| PKA | lox-PKAchu | AKAREV | B6-Tg(AKAR3EV)pT2A-lox-tdKeima-3901NES | nbio_208 | Cre-inducible |
Goto 2015;
Yamaguchi 2015;
Genotyping |
|
| PKA | Balb/c.lox-tdKeima-PKAchu | AKAREV | Balb/c-Tg(AKAR3EV)pT2A-lox-tdKeima-3901NES | nbio_285 | Cre-inducible | ||
| PKA | B6 Albino-PKAchu, hairless | AKAREV | B6 albino, hairless-Tg(AKAR3EV)pT2A-3901NES | nbio_318 | Ubiquitous | Konagaya 2017; Sato 2020 | |
| PKA | B6 Albino-lox-tdKeima-PKAchu | AKAREV | B6 albino-Tg(AKAR3EV)pT2A-lox-tdKeima-3901NES | nbio_320 | Cre-inducible | ||
| PKA | B6 Albino-lox-mCherry-Booster-PKA | lox-Booster-PKA | B6 albino-Tg(Booster-PKA)pT2ADW-lox-mCherry-NLS-Booster-PKA | nbio_371 | Cre-inducible | Watabe 2020 | |
| PKA | B6 Albino-Booster-PKA | Booster-PKA | B6 albino-Tg(Booster-PKA)pT2ADW-lox-mCherry-NLS-Booster-PKA | Under preparation. | Ubiquitous | Watabe 2020 | |
| AMPK | lox-AMPK | AMPKAREV | B6.Tg(lox-Eevee-AMPK)pT2A-lox-tdKeima-4031NES | nbio_268 | Cre-inducible | Konagaya 2017 | |
| AMPK | AMPAM | AMPKAREV | B6.Tg(AMPK)pT2A-4031NES | nbio_275 | Ubiquitous | Konagaya 2017 | |
| AMPK | AMPKAREV | B6-Tg(hyBRET-AMPK)pT2A-6034NES | nbio_327 | Ubiquitous | |||
| S6K | lox-S6K | Eevee-S6K | B6.Tg(lox-Eevee-S6K)pT2A-lox-tdKeima-3568NES | nbio_269 | Cre-inducible | ||
| S6K | hyBRET-S6K | B6-Tg(hyBRET-S6K)pT2A-6015NES | nbio_328 | Ubiquitous | |||
| TAK1 | hyBRET-TAK1 | B6-Tg(hyBRET-TAK1)pT2A-6035NES | nbio_329 | Ubiquitous | |||
| ROCK1 | B6 Albiono-ROCK | Eevee-ROCK | B6N-Tyrc-Brd/BrdCrCrl-Tg(Eevee-ROCK)pT2A-4146NES | Under preparation. | Ubiquitous | Imanishi 2021 | |
| CrkII | lox-Picchu-B6 | Picchu | B6C3F1-Tg(pT2A-lox-tdKeima-Picchu-734)#1 | nbio_221 | Cre-inducible | ||
| CrkII | lox-Picchu-FVB | Picchu | (FVBxB6C3F1)F1-Tg(pT2A-lox-tdKeima-Picchu-734)#1 | nbio_222 | Cre-inducible | ||
| CrkII | lox-Picchu-ICR | Picchu | (ICRxB6C3F1)F1-Tg(pT2A-lox-tdKeima-Picchu-734)#2 | nbio_223 | Cre-inducible | ||
| Negative control | PKAchu-NC | AKAREV-NC | ICR×(ICR×B6C3F1)N2-Tg(pT2A-3906NES)#2 | nbio_186 | Ubiquitous | Kamioka 2012; Sato 2020; AKAREV without phosphorylation site | |
| Negative control | B6 Albino-PKAchu-NC | AKAREV-NC:Albino hairless | B6 Albino-Tg(pT2A-3906NES) | nbio_319 | Ubiquitous |
Konagaya 2017;
Sato 2020;
Genotyping |
|
| Low molecular weight GTPases | |||||||
| Cdc42 | Raichu-Cdc42 | B6.Tg(Raichu-Cdc42)pT2A-Raichu-2253x | nbio_191 | Ubiquitous | Goto 2013 | ||
| Ras | FVB.lox-HRas | Raichu-HRas | FVB-Tg(lox-Raichu-HRas)pT2A-lox-tdKeima-Raichu-3715x | nbio_218 | Cre-inducible | ||
| Phosphoinositides | |||||||
| PI3,4P2 | Pippi-PI3,4P2 | (ICR×B6C3F1)F1-Tg(pT2A-1759xRe) | nbio_191 | Ubiquitous | |||